Neurohistological changes in the cerebellar cortex of adult Wistar rats following lead acetate induced cortical damage
نویسندگان
چکیده
This study investigated the neurohistological effect of lead acetate on cerebellar cortex adult wistar rats. Lead is a common industrial poisonous substance that its prevalence in environment exhibits toxic which makes different organs & tissues especially central nervous system vulnerable to exposure. however, found useful applications diverse items daily needs like paints, water pipes, car batteries, leaded gasoline, ammunition, cosmetics, hair dye, airplanes, shielding for x-ray machines. Thirty-six (36) rats both sexes weighing between 120-250 grams were randomly grouped into four groups. Group A, B, C and D each group containing seven (9) A served as control, was maintained standard feed 28 days, treated orally once with 0.09g/kg, 0.18g/kg 0.2g/kg respectively days. The weights recorded weekly basis during treatment. All sacrificed by cervical dislocation 29th day brain removed weighed sensitive balance cerebellum then fixed 10% formol saline, tissue processed stained Hematoxylin Eosin histological study. Results showed mean body significantly decreased groups when compared control group. significant decrease Histological (cerebellar cortex) demonstrated degenerative changes revealed shrinkage, reduced sized cellular loss Purkinje cells vacuolations cell layer normal histoarchitecture control. concluded has neurotoxic may ultimately impair some functions.
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ژورنال
عنوان ژورنال: GSC biological and pharmaceutical sciences
سال: 2021
ISSN: ['2581-3250']
DOI: https://doi.org/10.30574/gscbps.2021.15.3.0141